Sisters' cells may unlock genetic mystery

Sisters' cells may unlock genetic mystery

As siblings, Hayley and Bari Mogul share biological characteristics.

Unfortunately one that they share is a rare metabolic disorder that causes dangerously low blood sugar whenever they get ill or stressed out.

But, as also happens, the siblings have differences.

Chicago-area sisters Hayley and Bari Mogul are undergoing therapy at The Children's Institute while researchers study their gene mutations with hope of eventual treatment for others.

So along with a shared metabolic disorder, Hayley, 15, has a mutation of the RAI1 gene resulting in the Smith-Magenis syndrome with its characteristic effects -- obesity, a sleep disorder and behavioral problems. Bari, 9, has a mutation in her GRIN2B gene, causing neurological and development problems in the autism spectrum.

Read more here.

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